Biocine® Syrup 100ml (Lincomycin Hydrochloride 250mg/5ml)

BiocineĀ® Syrup 100ml (Lincomycin Hydrochloride 250mg/5ml)BIOCINE® (LINCOMYCIN HYDROCHLORIDE) Capsules
500mg, Syrup 250mg/5ml and injection 600mg/2ml

COMPOSTION
Each Biocine® capsule contains Lincomycin Hydrochloride equivalent to 500mg Lincomycin base. Each ml of the sterile solution contains Lincomycin Hydrochloride equivalent to 300mg/ml Lincomycin base in 2ml ampoules. Each 5ml (teaspoonful) Biocine® Syrup contains Lincomycin Hydrochloride equivalent to 250mg Lincomycin base.

INDICATIONS
Biocine® has been shown to be very effective in the treatment of the following conditions caused by gram-positive aerobes such as Streptococci, Pneumococci and Staphylococci (including penicillinase-producing staphylococci) or by susceptible anaerobic bacteria

1.

Bone and joint infections including osteomyelitis and septic arthritis

2.

Skin and soft tissue infections such as celllulitis, abscesses, furuncles, impetigo acne and wound infections.

3.

Upper respiratory infections including tonsilitis, pharyngitis, otitis media, finufits, scarlet fever and as adjuvant therapy for diphtheria.

4.

Lower respiratory infections such as acute and chronic bronchitis- and pneumonia.

5.

Septicaemia and endocarditis

6.

Bacillary dysentary

7.

Usage in Neonates. Biocine® is well tolerated in neonates and no adverse effects were reported.

DOSAGE AND ADMINISTRATION
Biocine® capsules, Biocine® Steriles solution, Biocine® Syrup

  Orals Intramuscular Intravenous
Adults 500mg three times daily 600mg (2ml) every 24 hours 600mg (2ml) to 1g every 8 to 12 hours. Administer in an infusion of 5% glucose in water or normal saline
Severe 500mg(or more) four times daily 600mg(2ml) every 12 hours  
Children 30mg/kg/day in 3 to 4 equal doses 10mg/kg every 24 hours 10 to 20mg/kg/day in two or three doses at 8 to 12 hour
intervals.Administer as infusion as for adults.
Severe 60mg/kg/day in 3 or 4 equal doses 10mg/kg every 12 hours

Biocine® should not be injected intravenously as a bolus. Intravenous doses are given on the basis of 1gm of Biocine® diluted in not less than 100ml of appropriate solution and infused over a period of not less than one hour.

Dose Vol. Diluent Time
600mg 100ml 1hr
1gm 100ml 1hr
2gm 200ml 2hr
3gm 300ml 3hr
4gm 400ml 4hr
Biocine® Syrup (Children over one month of age)
Weight Age Dosage (1 teaspoonful equals 5ml)
5-7kg
7-15kg
15-23kg
23-30kg
30-45kg
Birth - 1 yr
1 - 5 yrs
5 - 9 yrs
9 - 12 yrs
12 - 18 yrs
¼ teaspoonful four times a day
½ teaspoonful four times a day (Calculated as 30-60mg/kg/day)
1 teaspoonful three times a day
1 teaspoonful four times a day
2 teaspoonful three times a day
Over 45kg Over 18 yrs 2 teaspoonful four times a day

For optimal absorption, It is recommended that nothing should be given by mouth except water for a period of one to two hours before and after oral administration of Biocine®

SIDE EFFECTS
1. Skin mucous membrane: Pruritis, skin rashes, urticaria, vaginitis
2. Gastrointestinal - Nausea, vomiting, abdominal distress and persistent diarrhoea
3. Haematopoietic- Leucopenia, Neutropenia, agranulocytosis and thrombocytopenic purpura
4. Cardiovascular- instances of hypotension following parental administration have been reported especially after rapid administration.
5. Liver-Jaundice and abnormal liver function tests have been observed during Lincomycin therapy

CONTRAINDICATIONS
Biocine® is contra-indicated in patients previously found sensitive to Lincomycin or Clindamycin.

PRESENTATION
Biocine® Capsules: Each capsule contains Lincomycin hydrochloride equivalent to 500mg Lincomycin base blister pack of 2X10's.
Biocine® Sterile Solution: Each ml contains Lincomycin hydrochloride equivalent to 300mg/ml Lincomycin base in 2ml ampoules.
Biocine® Syrup: Each 5ml (teaspoonful) contains Lincomycin hydrochloride equivalent to 250mg Lincomycin base in 60ml bottles.

NAFDAC REGISTRATION NUMBER:
Biocine® Capsules -04-5587
Biocine® Syrup 100ml, 250mg/5ml -04-7530

Manufactured by
DRUGFIELD PHARMACEUTICALS LIMITED
Lynson Chemical Avenue,
KM 38, Lagos Abeokuta Expressway,
Sango Otta, Nigeria.