Compi-Clox® Dry Syrup 100ml (Ampicillin Trihydrate 125 mg + Cloxacillin Sodium 125 mg/5ml)

Compi-CloxCOMPI-CLOX®
Brand of Ampicilin + Cloxacillin for Oral usage

 

COMPI-CLOX® is a combination of Ampicillin as Trihydrate and Penicillinase resistant Cloxacillin as sodium salt to form broad spectrum antibiotic preparation. COMPI-CLOX® exhibits bactericidal activity against a broad range of Gram-positive and Gram-negative organisms such as Streptococcus species, staphylococcus species, Salmonella species, Haemophilus influenza, Eshericia-coli, Proteus mirabilis and Neisseria species.

ABSORPTION AND EXCRETION
Ampicillin and Cloxacillin are both acid stable and are easily absorbed, producing good serum and urine concentrations. COMPI-CLOX® is mainly excreted by glomerular filtration and renal tubular secretion.

INDICATIONS
COMPI-CLOX® is effective in the treatment of respiratory tract infections, Ear, Nose and throat infections. Uniary tract infections, Gastro- intestinal infections, skin and soft tissue infections. Pelvic infections, Septicaemia, Endocarditis, Orthopaedic infections. COMPI-CLOX® Neonatal Oral drops is indicated for the prophylaxis or treatment of bacterial infections in premature babies or neonates.

DOSAGE AND ADMINISTRATION
Administer COMPI-CLOX® ½ hour-1hour before meals or feeding.
DROPS- Neonates: 0.5ml (90mg) - 4 times daily or as by the physician. See 0.5ml mark on the dropper
SYRUP- Children: 1 month-2years- ½ - 1 teaspoonful 4times daily
2-10 years-1-2 teaspoonful 4times daily.
CAPSULE-Adult: one or two capsules 4times daily or as directed by a physician.

CONTRAINDICATIONS
Hypersensitivity to Penicillin

SIDE EFFECTS:
The side effects of COMPI-CLOX® as with other Penicillin are usually of mild and transitory nature. They may include Diarhoea, indigestion or occasionally rash-either utrticaria which suggest penicillin hypersensitivity or erythematous.

PREPARATION OF THE SUSPENSION
To make 100ml of the suspension, add 80ml of boiled and cooled water, while 10ml (two teaspoonful) of the water is added to Neonatal Oral drops to make 12ml suspension. Invert and shake the bottle until all powder is dispersed. Alternstively for 100ml suspension, add boiled and cooled water to half of the bottle, shake well and slowly add more water up to the mark on the label.

SHAKE WELL BEFORE TAKING EACH DOSE

STORAGE
All COMPI-CLOX® containers should be kept tightly closed and stored in a cool dry place below 25 0C. The suspension should be used within 7 days of preparation and stored in a cool place preferably a refrigerator.

PRECAUTION:
Reduced dosage is required in patients with impaired functions e.g. renal failure, neonates and pre-mature infants.

KEEP OUT OF THE REACH OF CHILDREN

COMPOSITION AND AVAILABILITY
NEONATAL ORAL DROPS
: 90mg drops: When reconstituted each 0.5ml contains 60mg Ampicillin as Ampicillin Trihydrate B.P. and 30mg Cloxacillin as the Sodium Salt B.P.
SUSPENSION: 250mg Dry Syrup: When reconstituted each 5ml contains 125mg Ampicillin as the Trihydrate B.P. plus 125mg Cloxacillin as the Sodium Salt B.P.
CAPSULES: 500mg: 250mg Ampicillin as Ampicillin Trihydrate B.P. and 250mg Cloxacillin as Cloxacillin Sodium Salt B.P. in Blister and 500's packs.

NAFDAC REGISTRATON NUMBER:
Compi-Clox Dry Syrup x 100ml -04-2350
Compi-Clox Neo-natal Drops -04-2128
Compi-Clox Capsules x 500s, x 100s, x 20s -04-3403

Manufactured by
DRUGFIELD PHARMACEUTICALS LIMITED
Lynson Chemical Avenue,
KM 38, Lagos-Abeokuta Expressway,
Sango-Otta, Nigeria